Celebrex should be swallowed whole with a drink of water. The capsules can be taken at any time of the day, with or without food. However, try to take each dose of Celebrex at the same time each dayFor osteoarthritis the usual dose is 200 mg each day, increased by your doctor to a maximum of 400 mg, if needed.For rheumatoid arthritis the usual dose is 200 mg each day, increased by your doctor to a maximum of 400 mg, if needed