1.Only use one patch at a time.2.A single patch could be applied for up to 8 to 12 hours.3.If pain occurs again 8 to 12 hours after applying the first patch, a second patch could be applied. Remove the first patch before applying a new patch.Salonpas Pain Relief Patch is suitable for adults and should not be used by children and adolescents under 18 years of age.